Sanjecumins A and B: New limonoids from Sandoricum koetjape

Nagakura, Y.^a,

Nugroho, A.E.^a,

Hirasawa, Y.^a,

Hosoya, T.^a,

Rahman, A.^b,

Kusumawati, I.^b,

Zaini, N.C.^b,

Morita, H.^a 

^a  Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan
^b  Faculty of Pharmacy, Airlangga University Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia 

Abstract

Two new limonoids, sanjecumins A (1) and B (2), have been isolated from the leaves of Sandoricum koetjape, together with sandoripins A (3) and B (4). Their structures and absolute configurations were elucidated on the basis of NMR and CD data. Sandoripins A (3) and B (4) moderately inhibited nitric oxide production in mouse macrophage-like cell line J774.1 stimulated by lipopolysaccharide. © 2012 The Japanese Society of Pharmacognosy and Springer.

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http://link.springer.com/article/10.1007%2Fs11418-012-0677-4